Virtual Tumour™

Learn about our proprietary cancer simulation tool
used to improve drug development success

What is Virtual Tumour™?

Virtual Tumour™ is our advanced, predictive modelling simulation tool used worldwide by global pharmaceuticals to small biotech companies to support oncology R&D.

Why Virtual Tumour™ is a Partner of Choice in Oncology Drug Development?

Our Virtual Tumour™ platform is one of the industry’s most advanced predictive models focused solely on oncology, predicting optimal drug dosing, scheduling and combinations.

Improve Success Rate

Improve success rates for oncology candidates entering clinical studies by increasing efficacy

Save Time

Reduce the time taken to do proof-of-principle studies

Reduce Cost

Reduce the cost of in vivo study programmes (fewer experiments needed)

Support with Regulatory Rationale

Provide regulatory agencies with a rationale for the design of clinical study programmes.

How Does it Work?

Virtual Tumour™ works by predicting the effects of cancer treatment regimes, simulating the growth or shrinkage of tumours under the effects of any combination of anti-cancer agents.

1

Use established or de novo PK models.

Source tumour growth Inhibition/biomarker data from client or public domain.

Characterize MOA of agent(s).

2

Model key elements of cell cycle.

Calibrate model using available data.

Follow cancer cells over time as they die or divide.

3

Track the number of cells and mathematically distribute them in the growing layer of a tumour.

4

Track the tumour size / cell cycle phases / biomarker evolution over time.Predict effect of different regimens.

Key Features

Features Supported
Predict behaviour over a full time course, not just a single point in time
Powerfully and naturally combine the effects of drugs with different mechanism of actions (MOAs)
Allows complex dosing and scheduling options e.g. dosing holidays, to be simulated
New data can be quickly incorporated as it is generated in mouse or human trials
Can help explain the behaviour of combination regimes in terms of cellular effects (e.g. cell cycle synchronization, cell death, DNA damage)
Model revisions and additional simulations can be delivered in real-time to enable decision-making during early clinical trials.

Things You Should Know About Virtual Tumour™

It’s implemented in MATLAB

An industry standard platform used to develop mathematical models with over 3m users worldwide. Recognised by many regulatory authorities as a validated coding environment.

It’s been used in over 70 Projects

Virtual Tumour™ can be used to model a huge variety of targets, drugs, cell lines and human cancers. It can simulate agents from small molecules and biologics through radiation.

In addition to clinical data, can often be calibrated using public data

Physiomics team is expert at identifying, digitising and analysing public domain data that can often be used to support calibration of its models, especially for standard of care drugs.

Can simulate clinical and pre-clinical tumours

Virtual Tumour™ can simulate both tumour-bearing mice and human tumours to support translational decision making and Phase I and II study design.

Has been validated in blinded studies

We have successfully completed multiple blinded validation studies for commercial clients and have reproduced a number of these in posters and presentations at major conferences.

Is used by companies ranging from startups to global pharmaceuticals

Physiomics has completed projects for companies ranging from small biotech to large cap pharma. We also work on grant and academic collaborations.

Project Examples

We have extended our core Virtual Tumour™ model to cover a variety of specific client requirements.  Examples include:

Simulation of the emergence of resistant clones [Learn More]

Addition of immune-oncology module to simulate immune cell interaction with tumour [Learn More]

Development of DNA repair mechanism to separately model DNA single-strand breaks (SSB) and double-strand breaks (DSB) [Learn More]

Simulation of long term effect of radiation alone or in combination with other anti-cancer agents. [Learn More]

Virtual Tumour™ Explained In Just 90 Seconds

Watch our quick overview of Virtual TumourTM and how our unique system can help you deliver results

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