Population PK and NCA

Population PK (popPK) analysis allows you to characterise the relationship between dose and exposure for a given population.  By understanding factors that influence variability in these relationships, Physiomics can inform dosing decisions for patient sub-populations.  PopPK models can be combined with PD models to establish how variability in exposure affects response.


Non-Compartmental Analysis (NCA) is an effective analysis that helps you visualise and characterise drug exposure, clearance & half life, facilitating decision making and comparison to other drugs.


Physiomics has extensive experience of both popPK and NCA and can help you gain a thorough understanding of your drugs’ PK profile and inform clinical development dosing decisions.


Physiomics performed a PK assessment on a Phase1/2a study of BT1718, a first in class Bicycle Toxin Conjugate (BTC).

Figure from ESMO poster with Bicycle Therapeutics and CRUK showing AUC and Cmax vs dose for BT1718, a Bicycle Toxin Conjugate (BTC)

Why Partner With Us?

At Physiomics we combine diverse experience with a commitment to quality and scientific curiosity to develop robust and bespoke solutions for every project. We work collaboratively and flexibly to ensure we deliver what our clients need and offer further insight and direction to your project.


To find out more about our collaborations and partnerships, please click here [Partners]

Interested in speaking with a consultant?

We’ll arrange a brief consultation for you with a specialist in our team.