Population PK (popPK) analysis allows you to characterise the relationship between dose and exposure for a given population. By understanding factors that influence variability in these relationships, Physiomics can inform dosing decisions for patient sub-populations. PopPK models can be combined with PD models to establish how variability in exposure affects response.
Non-Compartmental Analysis (NCA) is an effective analysis that helps you visualise and characterise drug exposure, clearance & half life, facilitating decision making and comparison to other drugs.
Physiomics has extensive experience of both popPK and NCA and can help you gain a thorough understanding of your drugs’ PK profile and inform clinical development dosing decisions.