Frequently Asked Questions (pdf )

• Pharmacokinetics

• Pharmacodynamics

Literature

Publications

Using mammalian cell cycle simulation to interpret differential kinase inhibition in anti-tumour pharmaceutical development C Chassagnole, R.C. Jackson, N. Hussain, L. Bashir, C Derrow, J. Savin and D.A. Fell, BioSystems Volume 83, Issues 2-3, February-March 2006, pages 91-97. Reprint on request

Presentations (pdf )

Optimal cancer chronotherapeutics schedules using a Systems Biology approach - Chronotherapeutics of Seliciclib Dr. Christophe Chassagnole, COO Beyond Genome Conference 2008, San Francisco, CA, 8-11 June 2008.

Systems Biology for Cancer Drug Development Dr Adam Hardy, Senior Simulation Scientist BioTrinity 2008 Oxford - Quadrangle at Kassam, Oxford, UK, 15-16 April 2008.

Drug Discovery and the New Biology Pr David A Fell, CSO Biotuesday – Milton Park, Abingdon, UK, 20 February 2007.

The Power of Systems Biology for PK/PD Modelling Dr Christophe Chassagnole EPIC, London, UK, 22 June 2006.

Devlopping Virtual Tumours for Reduced Attrition Physiomics plc Beyond Genome: Pathway and Disease Modeling, San Francisco, CA, 19-21 June 2006.

Posters (pdf )

Optimal cancer chronotherapeutic schedules of Seliciclib revealed by a systems biology approach E Fernandez, A Hardy, D Orrell, L Ramsell, DA Fell and C Chassagnole AACR 2008, San Diego, CA, 12-16 April 2008.

Systems biology analysis of CYC116, a novel aurora kinase inhibitor C Chassagnole, E Fernandez, F Scaërou, C Snell, D Zheleva, DM Glover, RC Jackson, DA Fell AACR 2008, San Diego, CA, 12-16 April 2008.

Modelling DNA Damage-Induced Apoptosis A R Hardy, D Orrell, C M Snell, C Chassagnole, G Morris and D A Fell ICSB 2007, Long Beach, CA, 1-6 October 2007.

Virtual Tumour Modelling The Effect of Aurora Kinase Inhibitors on the Cell Cycle C Chassagnole, C M Snell, A R Hardy, A Finney, E Fernandez and D A Fell EBI, Cambridge, UK, 11-13 March 2007.

Cell Cycle Lab: using SystemCell® Technology for Multiple-Cell Simulations C Chassagnole, M Swat, C Derow, A Finney, C Snell, J Savin and DA Fell 6th International Conference on Systems Biology, October 2005.

Cell Cycle Simulations for Examining the Effects of Drugs Inhibiting Aurora Kinases According to Cancer Cell Phenotype C Chassagnole, M Swat, C Derow, A Finney, C Snell, J Savin and DA Fell 6th International Conference on Systems Biology, October 2005, Boston.

Model building in a systems biology company: the cell cycle control and apoptosis C Derow, C Snell, C Chassagnole, J Savin and D A Fell 1st FEBS Advanced Lecture Course - SysBio2005 - Systems Biology: From Molecules & Modeling To Cells in Gosau, Austria, March 2005.

Cell Cycle Lab: using SystemCell™ technology  for multiple-cell simulations for in vivo simulations C Derow, N Hussain, C Chassagnole, D A Fell and J Savin BTK conference  in Oxford September 2004

Patents

SystemCell Technology is a patented control system architecture covered by:

• US patent: 6,446,055 issued Sep 3 2002
• European Patent: 0937286

The priority date is November 5th 1996.

Physiomics is currently pursuing other patentable innovations relating to the pharmaceutical application of systems biology and SystemCell technology.

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